CV & Publications
Dagmar Timmann-Braun
Department of Neurology
Faculty of Medicine and University Clinic
University of Duisburg-Essen
phone +49 – 201 – 7233816, fax: +49 – 201 – 7235901
email Dagmar.Timmann-Braun@uni-duisburg-essen.de
Research areas:
Physiology and pathophysiology of the human cerebellum, role of the cerebellum in
motor control, learning and cognition, clinical neuroscience.
Academic education:
1988 MD, University of Tübingen
1990 Dr. med., University of Tübingen
1996 Specialist in Neurology
1998 Habilitation with the venia legendi for Neurology, University of Essen
Academic positions:
- 1989-1993 Intern/resident Department of Neurology, faculty of Medicine and University Clinic Essen
- 1993-1994 Postdoc at the Arizona State University, Tempe, and Barrow Neurological Institute, Phoenix, Arizona, USA
- 1994-1995 Postdoc at the R.D. Dow Neurological Sciences Institute, Portland, Oregon, USA
- 1995-1997 Resident Department of Neurology, faculty of Medicine and University Clinic Essen
- 1998-1999 Postdoc at the University of Western Ontario, Department of Physiology, London, Ontario, Canada
- since 2000 Associate Professor (C3) of Experimental Neurology, Department of Neurology, Faculty of Medicine and University Clinic Essen
- 2006 Visiting Scientist at the University of Western Ontario, Department of Physiology, London, Ontario, Canada
Further activities:
since 1997 Medical advisory board, German Heredo-Ataxia Society
since 2006 Deputy chairman of the Human research ethics committee, University Clinic Essen
since 2007 Founding member and treasurer, Society for Research on Cerebellum
Publications of the last 5 years:
- Schwabe, A., Drepper, J., Maschke, M., Diener, H.C. and Timmann, D., The role of the human cerebellum in short- and long-term habituation of postural responses, Gait & Posture, 2004, 19: 16-23.
- Richter, S., Maschke, M., Timmann, D., Konczak, J., Kalenscher, T., Illenberger, A.R. and Kalveram, K-T., Adaptive behavior of cerebellar patients during exposure to unfamiliar external forces, J. Mot. Behav., 2004, 36: 28-38.
- McNaughton, S., Timmann, D., Watts, S. and Hore, J., Overarm throwing speed in cerebellar subjects: effect of timing of ball release, Exp. Brain Res., 2004, 154: 470-478.
- Gerwig, M., Dimitrova, A., Maschke, M., Kolb, F.P., Forsting, M. and Timmann, D., Amplitude changes of unconditioned eyeblink responses in patients with cerebellar lesions, Exp. Brain Res., 2004, 155: 341-351.
- Timmann, D., Drepper, J., Calabrese, S., Bürgerhoff, K., Maschke, M., Kolb, F.P., Daum, I. and Diener, H.C., Sequence information improves associative learning in control subjects but not cerebellar patients, Cerebellum, 2004, 3: 75-82.
- Dimitrova, A., Kolb ,F.P., Elles, H.G., Maschke, M., Gerwig, M., Gizewski, E. and Timmann, D., Cerebellar activation during leg withdrawal reflex conditioning: an fMRI study, Clin. Neurophysiol., 2004, 115: 849-857.
- Maschke, M., Weber, J., Dimitrova, A., Bonnet, U., Bohrenkaemper, J., Sturm, S., Kindsvater, K., Mueller, B.W., Gastpar, M., Diener, H.C., Forsting, M. and Timmann, D., Age-related changes of the dentate nuclei in normal adults as revealed by 3D fast low angle shot (FLASH) echo sequence magnetic resonance imaging, J. Neurol., 2004, 251: 740-746.
- Richter, S., Kaiser, O., Hein-Kropp, C., Dimitrova, A., Gizewski, E., Beck, A., Aurich, V., Ziegler, W. and Timmann, D., Preserved verb generation in patients with cerebellar atrophy, Neuropsychologia, 2004, 42: 1235-1246.
- Gizewski, E., Timmann, D. and Forsting, M., Specific cerebellar activation during Braille reading in blind subjects, Hum. Brain Mapp., 2004, 22: 229-235.
- Kolb, F.P., Lachauer, S., Maschke, M. and Timmann, D., Classically conditioned postural reflex in cerebellar patients, Exp. Brain Res., 2004, 158: 163-179.
- Frings, M., Gerwig, M., Boenisch, R., Diener, H.C. and Timmann, D., Learning of sensory sequences in cerebellar patients, Learn. Mem., 2004, 11: 347-355.
- Ozimek, A., Richter, S., Hein-Kropp, C., Schoch, B., Gorißen, B., Kaiser, O., Gizewski, E., Ziegler, W. and Timmann, D., Cerebellar mutism: Report of four cases, J. Neurol., 2004: 251: 963-972.
- Richter, S., Matthies, K., Ohde, T., Dimitrova, A., Gizewski, E., Aurich, V., Beck, A. and Timmann, D., Stimulus-response vs. stimulus-stimulus-response learning in cerebellar patients, Exp. Brain Res., 2004, 158: 438-449.
- Schoch, B., Gorißen, B., Richter, S., Ozimek, A., Kaiser, O., Dimitrova, A., Regel, J.P., Wieland, R., Hövel, M., Gizewski, E. and Timmann, D., Do children with focal cerebellar lesions show deficits in shifting attention?, J. Neurophysiol.,
2004, 92: 1856-1866. - Nowak, D.A., Hermsdörfer, J., Rost, K., Timmann, D. and Topka, H., Proactive and reactive finger force control during catching in cerebellar degeneration, Cerebellum, 2004, 3: 227-235.
- Hermsdörfer, J., Nowak, D.A., Lee, A., Rost, K., Timmann, D. and Boecker, H., The representation of predictive force control and internal forward models: evidence from lesion studies and brain imaging, Cogn. Process. Int. Quart. Cogn. Sci., 2005, 6: 48-58 (review).
- Nowak, D.A., Hermsdörfer, J., Timmann, D., Rost, K. and Topka, H., Impaired generalization of weight-related information during grasping in cerebellar degeneration, Neuropsychologia, 2005, 43: 20-27.
- Frings, M., Antoch, G., Knorrn, P., Freudenberg, L., Timmann, D. and Maschke, M., Strategies in detection of the primary tumor in anti-Yo associated paraneoplastic cerebellar degeneration, J. Neurol., 2005, 252: 197-201.
- Richter, S., Schoch, B., Ozimek, A., Schnepf, B., Hein-Kropp, C., Kaiser, O., Hövel, M., Wieland, R., Gizewski, E., Ziegler, W. and Timmann, D., Incidence of dysarthria in children with cerebellar tumors: a prospective study, Brain Lang., 2005, 92: 153-167.
- Timmann, D., Gerwig, M., Maschke, M. and Kolb, F.P., Eyeblink conditioning in patients with hereditary ataxia: a one year follow-up study, Exp. Brain Res., 2005, 162: 332-345.
- Maschke, M., Maschke, M., Weber, J., Dimitrova, A., Bonnet, U., Bohrenkaemper, J., Sturm, S., Kindsvater, K., Mueller, B.W., Gastpar, M., Diener, H.C., Forsting, M. and Timmann, D., Vermal atrophy of alcoholics correlate with thiamine deficiency but not with dentate iron concentration as estimated by MRI, J. Neurol., 2005, 252: 704-711.
- Rost, K., Nowak, D.A., Timmann, D. and Hermsdörfer, J, Preserved and impaired aspects of predictive grip force control in cerebellar patients, Clin. Neurophysiol., 2005, 116: 1405-1414.
- Richter, S., Dimitrova, A., Hein-Kropp, C., Wilhelm, H., Gizewski, E. and Timmann, D. Cerebellar agenesis II: Motor and language functions, Neurocase, 2005, 11: 103-113.
- Konczak, J., Schoch, B., Dimitrova, A., Gizewski, E. and Timmann, D., Functional recovery of children and adolescents after cerebellar tumour resection, Brain, 2005, 128: 1428-1441.
- Richter, S., Dimitrova, A., Maschke, M., Gizewski, E., Beck, A., Aurich, V. and Timmann, D., Degree of cerebellar ataxia correlates with 3D-MRI based cerebellar volume in pure cerebellar egeneration, Eur. Neurol., 2005, 54: 23-27.
- Richter, S., Schoch, B., Kaiser, O., Groetschel, H., Dimitrova, A., Hein-Kropp, C., Maschke, M., Gizewski, E. and Timmann, D., Behavioral and affective changes in children and adolescents with chronic cerebellar lesions, Neurosci. Lett., 2005, 381: 102-107.
- Gerwig, M., Hajjar, K., Dimitrova, A., Maschke, M., Kolb, F.P., Frings, M., Thilmann, A.F., Forsting, M., Diener, H.C. and Timmann, D., Timing of conditioned eyeblink responses is impaired in cerebellar patients, J. Neurosci., 2005, 25: 3919-3931.
- Glickstein, M., Baizer, J.S., Brown, B.L. and Timmann, D., Finger use in monkeys and patients with cerebellar lesions, Cerebellum, 2005, 4: 189-197.
- Richter, S., Schoch, B., Kaiser, O., Groetschel, H., Hein-Kropp, C., Maschke, M., Dimitrova, A., Gizewski, E., Ziegler, W., Karnath, H.O. and Timmann, D., Children and adolescents with chronic cerebellar lesions show no clinically relevant signs of aphasia or neglect, J. Neurophysiol., 2005, 94: 4108-4120.
- Gizewski, E.R., Lambertz, N., Timmann, D. and Forsting, M., Differential cerebellar activation patterns in deaf subjects for perception of sign language and written text: correlation with cortical activations, Neuroreport, 2005, 16: 1913-1917.
- Kolb, F.P. and Timmann, D., Clinical Neuro-Cybernetics: Motor learning in neuronal systems, In: Deisboeck, T.S. and Kresh, J.Y. (Eds.), Complex Systems Science in Biomedicine, Springer, New York, 2006, pp. 507-533.
- Gizewski, E.R., Timmann, D. and Forsting, M., Insights in specific cerebellar and cerebral activations in blind subjects, CMIR (Current Medical Imaging Reviews), 2006, 2: 435-442.
- Gerwig, M., Haerter, K., Hajjar, K., Dimitrova, A., Maschke, M., Kolb, F.P., Thilmann, A.F., Gizewski, E. and Timmann, D., Trace eyeblink conditioning in human subjects with cerebellar lesions, Exp. Brain Res., 2006, 170: 7-21.
- Dimitrova, A., Zeljko, D., Schwarze, F., Redies, C., Maschke, M., Gerwig, M., Frings, M., Beck, A., Aurich, V., Forsting, M. and Timmann, D., Probabilistic 3D MRI atlas of the human cerebellar nuclei, NeuroImage, 2006, 30: 12-25.
- Schoch, B., Dimitrova, A., Gizewski, E.R. and Timmann, D., Functional localization in the human cerebellum based on voxelwise statistical analysis: a study of 90 patients, NeuroImage, 2006, 30: 36-51.
- Frings, M., Maschke, M., Gerwig, M., Diener, H.C. and Timmann, D., Learning of simple auditory and visual sequences in cerebellar patients, Cerebellum, 2006, 5: 206-211.
- Frings, M., Awad, N., Jentzen, W., Dimitrova, A., Kolb, F.P., Diener, H.C., Timmann, D. and Maschke, M., Involvement of the human cerebellum and brain stem in short-term and long-term habituation of the acoustic startle response: A serial PET study, Clin. Neurophysiol., 2006, 117: 290-1300.
- Gerwig, M., Hajjar, K., Frings, M., Dimitrova, A., Thilmann, A.F., Kolb, F.P., Forsting, M. and Timmann, D., Extinction of conditioned eyeblink responses in patients with cerebellar disorders, Neurosci. Lett., 2006, 406: 87-91.
- Frings, M., Dimitrova, A., Schorn, C.F., Elles, H.-G., Hein-Kropp, C., Gizewski, E.R., Diener, H.C. and Timmann, D., Cerebellar involvement in verb generation: an fMRI study, Neurosci. Lett., 2006, 409: 19-23.
- Dimitrova, A., De Greiff, A., Schoch, B., Gerwig, M., Frings, M., Gizewski, E.R. and Timmann, D., Activation of cerebellar nuclei comparing finger, foot and tongue movements as revealed by fMRI, Brain Res. Bull., 2006, 71: 233-241.
- Schoch, B., Konczak, J., Dimitrova, A., Gizewski, E.R., Wieland, R. and Timmann, D., Impact of surgery and adjuvant therapy on balance function in children and adolescents with cerebellar umours, Neuropediatrics, 2006, 37: 350-358.
- Nowak, D.A., Topka, H., Timmann, D. and Hermsdörfer, J., The role of the cerebellum for predictive control of grasping, Cerebellum, 2007, 6: 7-17 (review).
- Gerwig, M., Kolb, F.P. and Timmann, D., The involvement of the human cerebellum in eyeblink conditioning, Cerebellum, 2007, 6: 38-57 (review).
- Frank, B., Schoch, B., Richter, S., Frings, M., Karnath, H.O. and Timmann, D., Cerebellar lesion studies of cognitive function in children and adolescents – limitations and negative findings, Cerebellum, 2007, 6: 242-253 (review).
- Konczak, J. and Timmann, D., The effect of damage to the cerebellum on sensorimotor and cognitive function in children, Neurosci. Behav. Rev., 2007, 31:1101-1113 (review).
- Timmann, D. and Daum, I., Cerebellar contributions to cognitive functions: A progress report after two decades of research, Cerebellum, 2007, 6: 159-162 (Editorial).
- Nowak, D.A., Timmann, D. and Hermsdörfer, J., Dexterity in cerebellar agenesis, Neuropsychologia, 2007, 45: 696-703.
- Frank, B., Schoch, B., Hein-Kropp, C., Dimitrova, A., Hövel, M., Ziegler, W., Gizewski, E.R., Richter, S. and Timmann, D., Verb generation in children and adolescents with acute cerebellar lesions, Neuropsychologia, 2007, 45: 977-988.
- Kolb, T.F.B., Lachauer, S., Schoch, B., Gerwig, M., Timmann, D. and Kolb, F.P., Comparison of electrically evoked withdrawal reflex in cerebellar patients and healthy controls, Exp. Brain Res., 2007, 177: 493-508.
- Richter, S., Gerwig, M., Aslan, B., Wilhelm, H., Schoch, B., Dimitrova, A., Gizewski, E.R., Ziegler, W., Karnath, H.O. and Timmann, D., Cognitive functions in patients with MR-defined chronic focal cerebellar lesions, J. Neurol., 2007, 254: 1193-1203.
- Frings, M., Maschke, M. and Timmann, D., Cerebellum and cognition – no emperical evidence for reductive theories of philopsophy of mind, Cerebellum, 2007, 6: 328-334.
- Richter, S., Aslan, B., Gerwig, M., Wilhelm, H., Schoch, B., Dimitrova, A., Gizewski, E.R., Thilmann, A.F. and Timmann, D., Patients with chronic focal cerebellar lesions show no cognitive abnormalities in a bedside test, Neurocase, 2007, 13: 25-36.
- Kronenbuerger, M., Gerwig, M., Brol, B., Block, F. and Timmann, D., Eyeblink conditioning is impaired in subjects with essential tremor, Brain, 2007, 130:1538-1551.
- Weyer, A., Abele, M., Schmitz-Hübsch, T., Schoch, B., Frings, M., Timmann, D. and Klockgether, T., Reliability and validity of the Scale for the Assessment and Rating of Ataxia: A study in 64 ataxia patients, Mov. Dis., 2007, 22: 1633-1637.
- Schoch, B., Regel, J.P., Frings, M., Gerwig, M., Maschke, M., Neuhäuser, M. and Timmann, D., Reliability and validity of ICARS in focal cerebellar lesions, Mov. Dis., 2007, 22: 2162-2169.
- Gizewski, E.R., de Greiff, A., Maderwald, S., Timmann, D., Forsting, M. and Ladd, M.E., FMRI at 7 T: whole brain coverage and signal advantages even infratentorially?, NeuroImage, 2007, 37: 761-768.
- Muhl, C. and Timmann, D., Extrapyramidale Syndrome und Ataxien, In: Widder, B., Gaidzik, P. and Tegenthoff, M. (Eds.), RRN – Neurologisches Gutachten. 1. Auflage, Thieme-Verlag, Stuttgart, 2007, pp. 251-261.
- Klockgether, T. and Timmann, D., Erbliche und nicht erbliche Ataxien, In: Brandt, T., Dichgans, J. and Diener, H.C. (Eds.), Therapie und Verlauf neurologischer Erkrankungen, 5. Auflage, Kohlhammer, Stuttgart, 2007, pp. 1076-1088.
- Timmann, D, and Diener, H.C., Coordination and Ataxia, In: Goetz, C.G. (Ed.), Textbook of Clinical Neurology, 3nd edition, Saunders, Orlando, FL, 2007, pp. 307-325.
- Kutz, D.F., Wölfel, A., Timmann, D. and Kolb, F.P., Detection of changes in grip forces on a sliding object, J. Neurosci. Methods, 2007, 166: 250-258.
- Gizewski, E.R., de Greiff, A., Maderwald, S., Timmann, D., Forsting, M. and Ladd, M.E., The estimated value of 7-Tesla functional MRI, Clin. Neuroradiol., 2008, 18: 65-72 (review).
- Schöls, L., Arning, L., Schüle, R., Epplen, J.T. and Timmann, D., “Pseudodominant inheritance” of ataxia with ocular apraxia type 2 (AOA2), J. Neurol., 2008, 255: 495-501.
- Timmann, D., Brandauer, B., Hermsdörfer, J., Ilg, W., Konczak, J., Gerwig, M., Gizewski, E.R. and Schoch, B., Lesion-symptom mapping of the human cerebellum, Cerebellum, 2008, 7: 602-606 (review).
- Frank, B., Schoch, B., Hein-Kropp, C., Hövel, M., Gizewski, E.R., Karnath, H.O. and Timmann, D., Aphasia, neglect and extinction are no prominent clinical signs in children and adolescents with acute surgical cerebellar lesions, Exp. Brain Res., 2008, 84: 511-519.
- Dimitrova, A., Gerwig, M., Brol, B., Gizewski, E.R., Forsting, M., Beck, A., Aurich, V., Kolb, F.P. and Timmann, D., Correlation of cerebellar volume with eyeblink conditioning in healthy subjects and in patients with cerebellar cortical degeneration, Brain Res., 2008, 1198: 73-84.
- Gerwig, M., Esser, A.C., Guberina, H., Frings, M., Kolb, F.P., Forsting, M., Aurich, V., Beck, A. and Timmann, D., Trace eyeblink conditioning in patients with cerebellar degeneration: Comparison of short and long trace intervals, Exp. Brain Res., 2008, 187: 85-96.
- Kronenbuerger, M., Tronnier, V.M., Fromm, C., Coenen, V.A., Kiening, K.L. and Timmann, D., Thalamic deep brain stimulation improves eyeblink conditioning deficits in essential tremor, Exp. eurol., 2008, 211: 387-396.
- Timmann, D., Lee, P., Watts, S. and Hore, J., Kinematics of arm joint rotations in cerebellar and unskilled subjects associated with the inability to throw fast, Cerebellum, 2008, 7: 366-378.
- Schmitz-Hübsch, T., Coudert, M., Bauer, P., Giunti, P., Globas, C., Baliko, L., Filla, A., Mariotti, C., Rakowicz, M., Charles, P., Ribai, P., Szymanski, S., Infante, J., Abdo, W.F., Dürr, A., Timmann, D., Boesch, S., Fancellu, R., Rola, R., Depondt, C., Schöls, L., Zdienicka, E., Kang, J.-S., Döhlinger, S., Kremer, B., Tezenas du Montcel, S. and Klockgether, T., Spinocerebellar ataxia type 1, 2, 3 and 6: Disease severity and non-ataxia symptoms, Neurology, 2008, 71: 982-989.
- Schmitz-Hübsch, T., Giunti, P., Globas, C., Baliko, L., Filla, A., Mariotti, C., Rakowicz, M., Szymanski, S., Infante, J., van de Warrenburg, B.P.C., Timmann, D., Fancellu, R., Rola, R., Depondt, C., Schöls, L., Zdzienicka, E., Kang, J.-S., Döhlinger, S., Kremer, B., Tezenas du Montcel, S. and Klockgether, T., SCA Functional Index – usefulness of a compound performance measure in spinocerebellar ataxia patients, Neurology, 2008, 71: 486-492.
- Arning, L., Schöls, L., Cin, H., Souquet, M., Epplen, J.T. and Timmann, D., Identification and characterisation of large SETX gene duplication in AOA2, Neurogenetics, 2008,9: 295-299.
- Brandauer, B., Hermsdörfer, J., Beck, A., Aurich, V., Gizewski, E.R., Marquardt, C. and Timmann, D., Impairments of prehension kinematics and grasping forces in patients with cerebellar degeneration and the relationship to cerebellar atrophy, Clin. Neurophysiol., 2008, 119: 2528-2537.
- Globas, C., Tezenas du Montcel, S., Baliko, L., Boesch, S., Depondt, C., DiDonato, S., Durr, A., Filla, A., Klockgether, T., Mariotti, C., Melegh, B., Otto, S., Rola, R., Rakowicz, M., Ribai, P., Schmitz-Hubsch, T., Timmann, D., Van de Warrenburg, B.P., Bauer, P. and Schöls, L., Early symptoms in spinocerebellar ataxia type 1, 2, 3, and 6, Mov. Dis., 2008, 23: 2232-2238.
- Ilg, M., Giese, M.A., Gizewski, E.R., Schoch, B. and Timmann, D., The influence of focal cerebellar lesions on the control and adaptation of gait, Brain, 2008, 131:2913-2927.
- Kutz, D., Wölfel, A., Timmann, D. and Kolb, F.P., Dynamic torque during a precision grip task comparable to picking a raspberry, J. Neurosci. Meth., 2009, 177: 80-86.
- Timmann, D., Posture-role of cerebellum, In: Binder, M.D., Hirokawa, N. and Windhorst, U. (Eds.), Encyclopedia of Neuroscience, Springer Verlag, Berlin, Heidelberg, 2009, DOI 0.1007/978-3-540-29678-2_4722.
- Rabe, K., Brandauer, B., Li, Y., Gizewski, E.R., Timmann, D. and Hermsdörfer, J., Size-weight illusion, anticipation and adaptation of fingertip forces in patients with cerebellar degeneration, J. Neurophysiol., EPUB ahead of print.
- Nowak, D.A., Hufnagel, A., Ameli, M., Timmann, D. and Hermsdörfer, J., Interhemispheric transfer of predictive force control during grasping in cerebellar disorders, Cerebellum, EPUB ahead of print.
- Werner, S., Bock, O. and Timmann, D., The effect of cerebellar cortical degeneration on adaptive plasticity and movement control, Exp. Brain Res., EPUB ahead of print.
- Buderath, P., Gärtner, K., Frings, M., Christiansen, H., Schoch, B., Konczak, J., Gizewski, E.R., Hebebrand, J. and Timmann, D., Postural and gait performance in children with attention deficit/hyperactivity disorder, Gait & Posture, EPUB ahead of print.
- Timmann, D., Konczak, J., Ilg, W., Donchin, O., Hermsdörfer, J., Gizewski, E.R. and Schoch, B., Current advances in lesion-symptom mapping of the human cerebellum, Neuroscience, (in press) review).
- Rabe, K., Livne, O., Gizewski, E.R., Aurich, V., Beck, A., Timmann, D. and Donchin, O., Adaptation to visuomotor rotation and force field perturbation is correlated to different brain areas in patients with cerebellar degeneration, J. Neurophysiol., (in press).